@article{Muhammad_Mabood_Rehman_Sattar_Mustafa_2011, title={Estimation of Acetylcholinesterase Activity in Addiction}, volume={8}, url={https://jpmi.org.pk/index.php/jpmi/article/view/470}, abstractNote={<table border="0" cellspacing="0" cellpadding="0" width="446"><colgroup span="1"><col span="1" width="446"></col></colgroup><tbody><tr height="153"><td class="xl65" width="446" height="153">Clinical and experimental evidence suggests that the use of morphine and its major derivative (heroin) plays a role in the alteration of acetylcholinesterase (Ach E) activity. We studied Ach. E activity in 80 heroin addicts hospitalized for detoxification. The activity of the enzyme was estimated by the method of ellman GL at 30c and pH 7.4 using acetylthiocholine iodide as substrate. The Michaelis during and psot treatment. The results showed that Ach e activity was suppressed during addiction, showing denaturation of the enzyme. The activity was regained after detoxification.</td></tr></tbody></table>}, number={2}, journal={Journal of Postgraduate Medical Institute}, author={Muhammad, Shereen and Mabood, FS and Rehman, Inayat ur and Sattar, Abdul and Mustafa, Ahmad}, year={2011}, month={Aug.} }