TY - JOUR AU - Ullah, Hidayat AU - Ashfaq, Shazia PY - 2011/12/29 Y2 - 2024/03/29 TI - AGE RELATED WHITE MATTER LESIONS ON MAGNETIC RESONANCE IMAGING JF - Journal of Postgraduate Medical Institute JA - J Postgrad Med Inst VL - 26 IS - 1 SE - Original Article DO - UR - https://jpmi.org.pk/index.php/jpmi/article/view/1197 SP - AB - <strong><em><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><p>Objective:</p></span></strong></span></strong></span><p> </p></em></strong><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;"><em><p><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;">To find out the frequency of cerebral white matter lesions (WML) in elderly individuals with no</span><strong><em><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><p>Methodology:</p></span></strong></span></strong></span><p> </p></em></strong><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;"><em><p><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;">This descriptive study was carried out at Radiology Department, Military Hospital,<p>Rawalpindi; January to December 2003. One hundred asymptomatic patients of either gender, aged 50</p><p>years and more without a known systemic disease were selected and divided into two groups of age 50-65</p><p>years and more than 65 years and MRI brain was performed. WML when found were classified as</p><p>subcortical and periventricular hyperintensities and rated for both hemispheres simultaneously along with</p><p>regional distribution of the WML. Frequency of each type of WML was assessed in the sample.</p></span></p><p>Relationship with age and gender of patients was also sought.</p><strong><em><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><p>Results:</p></span></strong></span></strong></span><p> </p></em></strong><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;"><em><p><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;">Subcortical WML were present in 54% (n=54) of subjects. Periventricular WML were found in<p>19% (n=19) of study population. Both subcortical and periventricular WML were more frequently observed</p><p>in more than 65 years age group. However findings were not statistically significant (p-values = 0.8333 &amp;</p><p>0.3646 respectively). Periventricular white matter lesions were observed more commonly in males with</p><p>statistically significant distribution (p-value = 0.0018). Subcortical WML were also more frequently</p><p>observed in males. However the distribution was statistically insignificant (p-value =0.1566). Distribution</p><p>of subcortical WML was most frequent in frontal lobes (62.9%) followed by parieto-occipital regions</p></span></p><p>(33.3%).</p><strong><em><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><strong><span style="font-family: TimesNewRomanPSMT,BoldItalic; font-size: x-small;"><p>Conclusion:</p></span></strong></span></strong></span><p> </p></em></strong><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;"><em><p><span style="font-family: TimesNewRomanPSMT,Italic; font-size: x-small;">WML are a frequent finding on MRI brain of asymptomatic elderly individuals of either</span></p><p>gender with periventricular WML having a statistically significant preponderance in males.</p></em></span></em></span></em></span></p><p>neurological symptoms.</p></em></span> ER -