TY - JOUR AU - Ullah, Wali AU - Irfan, Muhammad AU - Khan, Shahid Abdur Rauf AU - Ghalib, Adnan AU - Khalil, Zia Uddin PY - 2021/03/20 Y2 - 2024/03/29 TI - ROLE OF TOPICAL NEPAFENAC IN PREVENTING INCREASE IN MACULAR THICKNESS AFTER PHACOEMULSIFICATION JF - Journal of Postgraduate Medical Institute JA - J Postgrad Med Inst VL - 34 IS - 4 SE - Original Article DO - UR - https://jpmi.org.pk/index.php/jpmi/article/view/2739 SP - AB - <p><strong>Objective</strong><strong>: </strong>To compare mean increase in macular thickness in patients using topical Nepafenac and standard treatment with standard treatment alone, after phacoemulsifation.<strong></strong></p><p><strong>Methodology</strong><strong>: </strong>This was a comparative cross sectional study which involved 84 patients operated for age related cataract. Pre-operative ocular coherence tomography was performed to document the central macular thickness and patients were randomly allocated to 2 groups. Group A received topical Nepafenac 0.1% in addition to the standard post-operative topical medication. Group B received only standard regimen of topical medications including antibiotics and steroids. Phacoemulsification was performed in both groups. Post-operative OCT was done to measure central macular thickness after 2 months of surgery. Mean increase in central macular thickness was compared between the two groups.<strong></strong></p><p><strong>Results: </strong>Out of 84 patients, males were 45 (53.57%) and females were 39 (46.42%). Male to female ratio was 1: 1.15.  Average age was 58.65 years <span style="text-decoration: underline;">+</span> 6.01 SD. The mean pre-operative macular thickness was 234.4 um <span style="text-decoration: underline;">+</span> 1.72 SD while the mean post-operative macular thickness was 240.07 um <span style="text-decoration: underline;">+</span> 11.43 SD. The mean increase in macular thickness was 6.85um <span style="text-decoration: underline;">+</span> 4.69SD. Group A (Nepafenac group) showed significantly lesser increase in macular thickness after cataract surgery as compared to Group B (Non- Nepafenac group).<strong></strong></p><p><strong>Conclusion: </strong>Topical Nepafenac is associated with less mean increase in macular thickness after cataract surgery. It has a prophylactic role and reduces the occurrence of post-operative macular edema.</p><p> </p><p> </p> ER -