TY - JOUR AU - Khan, Parhezgar PY - 2011/07/25 Y2 - 2024/03/28 TI - COMPARATIVE STUDY BETWEEN GRANISETRON, ONDANSETRON AND PROPOFOL FOR THE PREVENTION OF EMESIS AFTER GYNAECOLOGICAL LAPROSCOPY JF - Journal of Postgraduate Medical Institute JA - J Postgrad Med Inst VL - 19 IS - 2 SE - Original Article DO - UR - https://jpmi.org.pk/index.php/jpmi/article/view/29 SP - AB - <span style="font-family: Times New Roman; color: #1f1a17; font-size: x-small;"><span style="font-family: Times New Roman; color: #1f1a17; font-size: x-small;"><span style="font-family: Times New Roman; color: #1f1a17; font-size: x-small;"><p>Objective: The aim of this work was to evaluate the efficiency and safety of granisetron versus</p><p>ondansetron and Propofol for prevention of postoperative nausea and vomiting in patient undergoing day</p><p>case gynaecological laproscopy under general anaesthesia.</p><p>Material and Methods: This study was conducted in Alquwayiyah General Hospital and Riyadh Medical</p><p>Complex. K.S.A, over and period of six months, from January 2004 to June 2004 (both Months inclusive).</p><p>120 adult non pregnant female patients (18-40 yrs of age) of ASA I-II scheduled for diagnostic</p><p>gynaecological laproscopy were included in this study. Patients with severe systemic or endocrine disease</p><p>who had predisposing factors for delayed gastric emptying, such as diabetes, cholecystitis or</p><p>neuromuscular disorders were excluded.</p><p>Results: This study was conducted in 120 patients classified into six groups (20 patients each). The first</p><p>group received granisetron, the second group ondansetron, the third, fourth and fifth group received</p><p>propofol in different does. The last group received normal saline as placebo ( control group). Treatment</p><p>with either granisetron (group-I) and ondansetron (group-II) resulted in significant lower incidence of</p><p>nausea and vomiting over 12 hours observation postoperatively compared with other group. However</p><p>granisetron resulted in significant in lower incidence than ondansteron.</p><p>Conclusion: It is concluded that preoperative prophylactic administration of intravenous granisetron 40</p><p>ug/kg is effective and superior to ondansetron and propofol in preventing nausea and vomiting after</p><p>gynaecological laproscopic surgical procedures.</p></span></span></span> ER -