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Aziz un Nisa
Sultan Zeb
Ayesha Ghazanfar


Adult-onset Still’s disease (AOSD), also known as Wissler-Fanconi syndrome is a rare systemic disorder. Symptoms usually include fever, joint pain, and rash. The diagnosis of ASOD is mostly clinical and excludes other possible causes. In this case report, a 25 years old gentleman, who in the recent past was diagnosed and treated with septic and reactive arthritis. He presented to us with a salmon-colored rash along with arthritis and was diagnosed as AOSD on the basis of clinical criteria, leukocytosis, raised inflammatory markers i.e., serum ferritin after the exclusion of other conditions.

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Aziz un Nisa, Sultan Zeb, Ibrahim, Ayesha Ghazanfar. ADULT-ONSET STILL’S DISEASE: A FORGOTTEN MYTH. J Postgrad Med Inst [Internet]. 2022 Mar. 31 [cited 2024 Mar. 1];36(1):47-50. Available from:
Case Report


Still GF. On a form of chronic joint disease in children. Med Chir Trans. 1897;80:47-60.9.

Owlia MB, Mehrpoor G. Adult-onset Stills disease: A review. Indian J Med Sci. 2009; 63(5):207-21.

Kadavath S, Efthimiou P. Adult-onset Still’s disease-pathogenesis, clinical manifestations, and new treatment options. Ann Med. 2015;47(1):6–14.

Kim H-A, Han JH, Kim W-J, Noh HJ, An J-M, Yim H, et al. TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s a disease and their association with disease activity and clinical manifestations. Int J Mol Sci. 2016;17(8):1342.

Wang Z, Chi H, Sun Y, Teng J, Feng T, Liu H, et al. Serum sTREM-1 in adult-onset Still’s a disease: a novel biomarker of disease activity and a potential predictor of the chronic course. Rheumatology (Oxford). 2020;59(11):3293–302.

Feist E, Mitrovic S, Fautrel B. Mechanisms, biomarkers and targets for adult-onset Still’s disease. Nat Rev Rheumatol. 2018;14(10):603–

Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for the classification of adult Still’s disease. J Rheumatol. 1992;19(3):424–30.

Ortiz-Sanjuán F, Blanco R, Riancho-Zarrabeitia L, Castañeda S, Olivé A, Riveros A, et al. Efficacy of anakinra in refractory adult-onset Still’s disease: Multicenter study of 41 patients and literature review. Medicine (Baltimore) . 2015;94(39):e1554.

Sfriso P, Bindoli S, Doria A, Feist E, Galozzi P. Canakinumab for the treatment of adult-onset Still’s disease. Expert Rev Clin Immunol. 2020;16(2):129–38.

Ruscitti P, Rago C, Breda L, Cipriani P, Liakouli V, Berardicurti O, et al. Macrophage activation syndrome in Still’s disease: analysis of clinical characteristics and survival in paediatric and adult patients. Clin Rheumatol . 2017;36(12):2839–45.