SYSTEMATIC REVIEW AND META-ANALYSIS OF ASSOCIATION OF β2-ADRENERGIC RECEPTOR GENE POLYMORPHISMS WITH NOCTURNAL ASTHMA
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Published:
Aug 10, 2017
Keywords:
Nocturnal, Asthma, Genotype, Allele, Polymorphism, Meta-analysis
Main Article Content
Abstract
Objective: To integrate the quantitatively existing evidences on nocturnal asthma
and their association with β2-adrenergic receptor (Arg16Gly and Glu27Gln)
polymorphism.
Methodology: The whole procedure for systematic review and meta-analysis
was conducted following PRISMA guidelines. The following databases Ovid,
PubMed, Wiley online library, Springer link and the Web of Knowledge were
searched for relevant articles. Random effect meta-analysis was conducted.
Heterogeneity was evaluated by I2 statistic. The funnel plots and the Eager tests
were used to assess the small study biases and potential publications.
Results: This systematic review and meta-analysis comprised a total of 9 studies.
The brief statement estimates suggested heterozygous Arg/Gly (OR =2.32;
95% CI =1.53-3.54; P value =<0.001), homozygous Gly (OR =4.78; 95% CI =2.60-
8.77, P-value =<0.001) and Gly allele (OR =1.71, 95% CI =1.14-2.56, P-value
=0.009) was significantly associated with nocturnal asthma. While Glu27Gln
polymorphism did not showed significant association with nocturnal asthma
both in genotype (OR =1.28; 95% CI =0.63-2.59; P-value =0.496) and allelic (OR
=1.65; 95% CI =0.64-4.27; P-value =0.301) analysis.
Conclusion: Heterozygous Arg/Gly, homozygous Gly/Gly and Gly Allele were
found to be significantly associated with nocturnal asthma.
and their association with β2-adrenergic receptor (Arg16Gly and Glu27Gln)
polymorphism.
Methodology: The whole procedure for systematic review and meta-analysis
was conducted following PRISMA guidelines. The following databases Ovid,
PubMed, Wiley online library, Springer link and the Web of Knowledge were
searched for relevant articles. Random effect meta-analysis was conducted.
Heterogeneity was evaluated by I2 statistic. The funnel plots and the Eager tests
were used to assess the small study biases and potential publications.
Results: This systematic review and meta-analysis comprised a total of 9 studies.
The brief statement estimates suggested heterozygous Arg/Gly (OR =2.32;
95% CI =1.53-3.54; P value =<0.001), homozygous Gly (OR =4.78; 95% CI =2.60-
8.77, P-value =<0.001) and Gly allele (OR =1.71, 95% CI =1.14-2.56, P-value
=0.009) was significantly associated with nocturnal asthma. While Glu27Gln
polymorphism did not showed significant association with nocturnal asthma
both in genotype (OR =1.28; 95% CI =0.63-2.59; P-value =0.496) and allelic (OR
=1.65; 95% CI =0.64-4.27; P-value =0.301) analysis.
Conclusion: Heterozygous Arg/Gly, homozygous Gly/Gly and Gly Allele were
found to be significantly associated with nocturnal asthma.
Article Details
How to Cite
1.
Khan I, Ul Haq Z, Shaheen A, Afridi MZ, Ahmad N, Abassi R, Ahmad N, Siraj S. SYSTEMATIC REVIEW AND META-ANALYSIS OF ASSOCIATION OF β2-ADRENERGIC RECEPTOR GENE POLYMORPHISMS WITH NOCTURNAL ASTHMA. J Postgrad Med Inst [Internet]. 2017 Aug. 10 [cited 2024 Dec. 22];31(3). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/2105
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