ASSOCIATION OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION WITH ATRIAL FIBRILLATION AFTER CORONARY ARTERY BYPASS GRAFT SURGERY
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Abstract
Objective: To determine the association of Diastolic dysfunction in patients with atrial fibrillation after CABG surgery.
Methodology: This cross sectional study was conducted from 01st May, 2022 to 30th Nov, 2022 in department of Cardio-thoracic Anaesthesia and Adult Cardiac Critical care, AFIC/NIHD, Rawalpindi. 154 patients were assessed for preoperative diastolic dysfunction, and grade. After CABG, they were monitored for 24 hours in ICU for atrial fibrillation (AF). If there was AF, it was noted down.
Results: Most of our patients were male (81.2%). Mean age of patients was 58.69 ±8.25 years. Hypertension was present in 71.4% patients. Mean ejection fraction was 49.88±6.28%. Grade I diastolic dysfunction was present in 42.9% patients. Frequency of AF was 31.2%. Frequency of diastolic dysfunction (Grade 1 & 2) was higher in non-AFib group while Grade-3 dysfunction was higher in AFib group and the association was statistically significant (p<0.01). Mean difference of ejection fraction and hypertension status was also significantly associated with AFib status with p-values (p=0.007 and 0.034 respectively). All rest variables had insignificant findings with regard to AFib status (p>0.05).
Conclusion: Our study shows that grade III diastolic dysfunction is associated with increased frequency of post-operative
atrial fibrillation.
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References
Kuznetsova T, Herbots L, Lopez B, Jin Y, Richart T, Thijs L, et al. Prevalence of left ventricular diastolic dysfunction in a general population. Circ Heart Fail. 2009;2(2):105-12. DOI: 10.1161/circheartfailure.108.822627.
Dal Piaz EC, Cioffi G, Ognibeni F, Dalbeni A, Giollo A, Orsolini G, et al. Incidence and predictors of new onset left ventricular diastolic dysfunction in asymptomatic patients with rheumatoid arthritis without overt cardiac disease. Monaldi Arch Chest Dis. 2019;89(3). DOI: 10.4081/monaldi.2019.1053.
Nagueh SF. Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography. JACC Cardiovasc Imaging. 2020;13(1, Part 2):228-244.
Filardo G, Damiano RJ, Ailawadi G, Thourani VH, Pollock BD, Sass DM, et al. Epidemiology of new-onset atrial fibrillation following coronary artery bypass graft surgery. Heart Br Card Soc. 2018;104(12):985–92. DOI: 10.1136/heartjnl-2017-312150.
Mehaffey JH, Hawkins RB, Byler M, Charles EJ, Fonner C, Kron I, et al. Cost of individual complications following coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2018;155(3):875-882.e1. DOI: 10.1016/j.jtcvs.2017.08.144.
Dobrev D, Aguilar M, Heijman J. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. 2019; 417–436. DOI: 10.1038/s41569-019-0166-5.
Nagueh SF. Classification of Left Ventricular Diastolic Dysfunction and Heart Failure Diagnosis and Prognosis. J Am Soc Echocardiogr. 2018;31(11):1209-1211. DOI:10.1016/j.echo.2018.09.011.
Ashes CM, Yu M, Meineri M, Katznelson R, Carroll J, Rao V, et al. Diastolic dysfunction, cardiopulmonary bypass, and atrial fibrillation after coronary artery bypass graft surgery. Br J Anaesth. 2014;113(5):815-21. DOI: 10.1093/bja/aeu208.
Melduni RM, Suri RM, Seward JB, Bailey KR, Ammash NM, Oh JK, et al. Diastolic dysfunction in patients undergoing cardiac surgery: a pathophysiological mechanism underlying the initiation of new-onset post-operative atrial fibrillation. J Am Coll Cardiol. 2011;58(9):953-61. DOI: 10.1016/j.jacc.2011.05.021.
Rong LQ, Di Franco A, Rahouma M, Dimagli A, Patel A, Lopes AJ, et al. Baseline intraoperative left ventricular diastolic function is associated with postoperative atrial fibrillation after cardiac surgery. Anesthesiology. 2023; 139, 602–13. DOI: 10.1097/ALN.0000000000004725.
Degirmencioglu A, Senay S, Gullu U, Zencirci E, Karakus G, Ugur M, et al. The effect of mild left ventricular diastolic dysfunction on outcome after isolated coronary bypass surgery. Kardiol Pol. 2014;72(6):541-5. DOI: 10.5603/KP.a2013.0354.
Kyle B, Zawadka M, Shanahan H, Cooper J, Rogers A, Hamarneh A, et al. Consensus Defined Diastolic Dysfunction and Cardiac Postoperative Morbidity Score: A Prospective Observational Study. J Clin Med. 2021;10(21):5198. DOI: 10.3390/jcm10215198.
Brown JA, Yousef S, Zhu J, Thoma F, Serna-Gallegos D, Joshi R, et al. The Long-Term Impact of Diastolic Dysfunction After Routine Cardiac Surgery. J Cardiothorac Vasc Anesth. 2023;37(6):927-32. DOI: 10.1053/j.jvca.2023.01.036.
Jannati M. Atrial Fibrillation Post Coronary Artery Graft Surgery: A Review of Literature. Int J Gen Med. 2019;12:415-20. DOI: 10.2147/IJGM.S227761.
Rajput HAS, Khan F, Zargar UQ, Iqbal F, Shamim K, Wahab A, et al. Association of Atrial Fibrillation With Patient Characteristics in Postoperative Coronary Artery Bypass Grafting Surgery. Cureus. 2021;13(11):e19800. DOI: 10.7759/cureus.19800.
Filardo G, Damiano RJ Jr, Ailawadi G, Thourani VH, Pollock BD, Sass DM, et al. Epidemiology of new-onset atrial fibrillation following coronary artery bypass graft surgery. Heart. 2018;104(12):985-92. DOI: 10.1136/heartjnl-2017-312150.
Barbara DW, Rehfeldt KH, Pulido JN, Li Z, White RD, Schaff HV, et al. Diastolic function and new-onset atrial fibrillation following cardiac surgery. Ann Card Anaesth. 2015;18(1):8-14. DOI: 10.4103/0971-9784.148313.
Metkus TS, Suarez-Pierre A, Crawford TC, Lawton JS, Goeddel L, Dodd-O J, et al. Diastolic dysfunction is common and predicts outcome after cardiac surgery. J Cardiothorac Surg. 2018;13(1):67. DOI: 10.1186/s13019-018-0744-3.
Chua SK, Shyu KG, Lu MJ, Hung HF, Cheng JJ, Lee SH, et al. Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery. Circ J. 2013. Epub ahead of print. PMID: 23778183.