Estimation of Acetylcholinesterase Activity in Addiction
Main Article Content
Clinical and experimental evidence suggests that the use of morphine and its major derivative (heroin) plays a role in the alteration of acetylcholinesterase (Ach E) activity. We studied Ach. E activity in 80 heroin addicts hospitalized for detoxification. The activity of the enzyme was estimated by the method of ellman GL at 30c and pH 7.4 using acetylthiocholine iodide as substrate. The Michaelis during and psot treatment. The results showed that Ach e activity was suppressed during addiction, showing denaturation of the enzyme. The activity was regained after detoxification.
How to Cite
Muhammad S, Mabood F, Rehman I ur, Sattar A, Mustafa A. Estimation of Acetylcholinesterase Activity in Addiction. J Postgrad Med Inst [Internet]. 2011 Aug. 26 [cited 2023 May 31];8(2). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/470
Work published in JPMI is licensed under a
Creative Commons Attribution-NonCommercial 2.0 Generic License.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.