Estimation of Acetylcholinesterase Activity in Addiction

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Shereen Muhammad
FS Mabood
Inayat ur Rehman
Abdul Sattar
Ahmad Mustafa


Clinical and experimental evidence suggests that the use of morphine and its major derivative (heroin) plays a role in the alteration of acetylcholinesterase (Ach E) activity. We studied Ach. E activity in 80 heroin addicts hospitalized for detoxification. The activity of the enzyme was estimated by the method of ellman GL at 30c and pH 7.4 using acetylthiocholine iodide as substrate. The Michaelis during and psot treatment. The results showed that Ach e activity was suppressed during addiction, showing denaturation of the enzyme. The activity was regained after detoxification.

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Muhammad S, Mabood F, Rehman I ur, Sattar A, Mustafa A. Estimation of Acetylcholinesterase Activity in Addiction. J Postgrad Med Inst [Internet]. 2011 Aug. 26 [cited 2024 Jun. 16];8(2). Available from:
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