Sjogren Larsson Syndrome

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Raza Muhammad
Zahid Aslam
Kiramat Ali Shah


The Sjogren – Larsson Syndrome (SLS) is an autosomal recessive disorder. It is characterized by three cardinal symptoms; congenital ichthyosis, spastic diplegia or tetraplegia and mental retardation. SLS was first described by Sjogren in 1958, Sjogren and Larsson in 1957 and independently by Soderhjelm and Enell in 1957. The majority of patients have been reported from Sweden where the prevalence in certain region is as high as 1 in 12,000, although the diseases occurs world wide at a much lower frequency.

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Muhammad R, Aslam Z, Shah KA. Sjogren Larsson Syndrome. J Postgrad Med Inst [Internet]. 2011 Aug. 28 [cited 2023 Jun. 7];9(1). Available from:
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