Comparative Study of effects of Nifedipine and Isosorbide Dinitrate and Their Interaction on Isolated Rabbit Aortic Strips
Article Sidebar
Main Article Content
Abstract
Experiments were performed on Isolated Rabbit Aorta in order to study the action of nifedipine and isosorbide dinitrate on noradrenaline-evoked contractions. Contractions of aorta were obtained with increasing concertrations of noradrenaline. The tissue was kept in Krebs physiological salt solution. The effects were recorded with the help of narco Mark IV physiograph (USA). Both nifedipine and isosorbide dinitrate caused a decrease in amlitude of contractions of the aorta. However, none caused 100 percent inhibition of the evoked contractions. Percentage decrease in the amlitude of evoked contractions of the aorta caused by nifedipine was compared with the percentage decrease caused by isosorbide dinitrate. The effects of the combination of nifedipine + isosorb ide dinitrate on the aorta were compared with the effect of the individual test drugs.
Article Details
How to Cite
1.
Afridi AH, Nasim R, Khan HH, Cheema MA. Comparative Study of effects of Nifedipine and Isosorbide Dinitrate and Their Interaction on Isolated Rabbit Aortic Strips. J Postgrad Med Inst [Internet]. 2011 Sep. 9 [cited 2024 Nov. 21];13(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/639
Issue
Section
Original Article
Work published in JPMI is licensed under a
Creative Commons Attribution-NonCommercial 2.0 Generic License.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.