EFFECT OF FLUOXETINE ON THE SEXUAL BEHAVIOUR OF DROSOPHILA MELANOGASTER

Abstract

Objective:

Antidepressant drugs are administered in appropriate doses to get rid of depression. Most of

these drugs have adverse effects on sexual function. Selective serotonin reuptake inhibitors (SSRIs) are

antidepressants that cause sexual dysfunction. The effect of this drug on the sexual behaviour of

Drosophila melanogaster is studied here.

Methodology:

The male, female and both treated groups were used. The effect of fluoxetine (FLX) on the

sexual behavioural elements such as, orientation, tapping, wing vibration, scissoring, licking, circling,

extruding and decamping were observed. The F1 and F2 progeny obtained from inbreeding of the above

combinations were also used for observation. Three sub lethal concentrations (0.02, 0.04 and 0.06%) were

administered by larval feeding method

Results:

Most of the male courtship acts and the non-receptive behaviour of females are affected by

treatment of antidepressant drug in parents' generation. Sexual behaviour elements of male and female

were insignificant in F1 and F2 progeny.

Conclusion

the progeny. Therefore, the author is of the opinion that low concentrations of these drugs could be used

by man to get rid of depression.

: The LC and concentrations used are very high. Furthermore, these drugs have no effect on