Midtrimester pregnancy termination: Comparison of prostaglandin F2 alpha with misoprostol
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Abstract
Objective: To compare the efficacy and cost of misoprostol and prostaglandin F2 alpha (PGF2α) for mid-trimesterpregnancy termination.
Methodology: This comparative quasi experimental study was conducted in Department of Obstetrics andGynaecology, Lady Reading Hospital, Peshawar from September 2006 to August 2007. Total 100 pregnantwomen admitted for therapeutic termination pregnancy were included in the study that fulfilled the inclusioncriteria. Patients were randomly allocated into 2 equal groups by lottery method. Patients in group- Iwere induced with tablet misoprostol while patients in group-II were induced with extra-amniotic PGF2αinjection. In both groups, variables like induction delivery interval, duration of hospital stay, cost of drugsand side effects were measured. Data was analyzed by SPSS version 16.
Results: Induction delivery interval and hospital stay were shorter in Misoprostol group (P < .000). Misoprostolwas more economical compared with PGF2α (P < .000). Success rate was 100% with PGF2α and96% with misoprostol. However, side effects were common with PGF2α (P < .001).
Conclusion: Misoprostol is a very effective and economical drug for mid-trimester pregnancy termination.
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