CRP, AN INFLAMMATORY BIOMARKER IN TYPE 2 DIABETES MELLITUS
Article Sidebar
Main Article Content
Abstract
Objective: To find out hs-CRP levels in type 2 diabetic patients with and withoutCHD and to further evaluate association of hs-CRP with glycosylated hemoglobinand lipid profile.
Methodology: A cross- sectional / analytical study was conducted. Group Acomprised of 100 type 2 diabetic patients without CHD and Group B comprisedof 100 type 2 diabetic patients with CHD. All the patients were randomlyselected from Khyber teaching hospital (KTH) and Hyatabad MedicalComplex (HMC). Blood Glucose, Glycosylated Hemoglobin, Lipid profile andhs-CRP levels were assessed.
Results: The mean hs-CRP, FBS and glycosylated hemoglobin values were significantly(P< 0.05) high in type 2 diabetic patients having CHD than type 2diabetic patients without CHD. Moreover, hs-CRP also showed a significant(P< 0.05) positive association with FBS and HbAlc and negative associationwith HDL-C (P< 0.05).
Conclusion: It can be concluded from the study that raised levels of plasmahs-CRP in type 2 diabetic patients may contribute to ongoing atheroscleroticprocesses leading to the development of coronary heart disease in these patientsand this can be used as a marker of development of atherosclerosis inpatients with diabetes mellitus.
Article Details
Work published in JPMI is licensed under a
Creative Commons Attribution-NonCommercial 2.0 Generic License.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.