ENDOTHELIAL DYSFUNCTION AND DERANGED LEVEL OF ASYMMETRIC DIMETHYL ARGININE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
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Published:
Dec 12, 2015
Keywords:
Type 2 diabetes, Coronary artery disease (CAD), ADMA, HbA1c, TC, Lipid profile, TG
Main Article Content
Abstract
Objective: To determine the serum Asymmetric dimethyl arginine (ADMA)
level, association of various biochemical parameters with plasma ADMA level
in type 2 diabetic patients and also to compare with normal healthy individ -uals.
Methodology: Analytical cross sectional study was conducted at Medical and
Cardiology Departments of Khyber Teaching Hospital (KTH) and Hayatabad
Medical Complex (HMC), Peshawar for a period of one year. A total of 140
participants with age range of 35-65 years, were divided into two groups.
Blood was obtained from each participant for biochemical analysis. All data
obtained was entered in SPSS version 15. A P-value of < 0.05 was considered
as statistically significant.
Results: An elevated ADMA was noted group B. In group A significant posi -tive correlation was observed between serum ADMA with TC and TG level and
a non-significant correlation was observed between ADMA and HDL level.
In case of group B a significant strong positive linear relationship was seen
between ADMA level and different parameters like FBG, HbA1c, LDL and no
significant correlation was seen between ADMA with TG and TC.
Conclusion: Our study reveals increased serum ADMA levels in the patients
suffering from type 2 diabetes mellitus without CAD when compared with the
control group. Also a significant positive correlation was seen between serum
ADMA level and FBS, HbA1c, TC, HDL-C and TG levels among the subjects of
group B.
level, association of various biochemical parameters with plasma ADMA level
in type 2 diabetic patients and also to compare with normal healthy individ -uals.
Methodology: Analytical cross sectional study was conducted at Medical and
Cardiology Departments of Khyber Teaching Hospital (KTH) and Hayatabad
Medical Complex (HMC), Peshawar for a period of one year. A total of 140
participants with age range of 35-65 years, were divided into two groups.
Blood was obtained from each participant for biochemical analysis. All data
obtained was entered in SPSS version 15. A P-value of < 0.05 was considered
as statistically significant.
Results: An elevated ADMA was noted group B. In group A significant posi -tive correlation was observed between serum ADMA with TC and TG level and
a non-significant correlation was observed between ADMA and HDL level.
In case of group B a significant strong positive linear relationship was seen
between ADMA level and different parameters like FBG, HbA1c, LDL and no
significant correlation was seen between ADMA with TG and TC.
Conclusion: Our study reveals increased serum ADMA levels in the patients
suffering from type 2 diabetes mellitus without CAD when compared with the
control group. Also a significant positive correlation was seen between serum
ADMA level and FBS, HbA1c, TC, HDL-C and TG levels among the subjects of
group B.
Article Details
How to Cite
1.
Tariq K, Khan MA. ENDOTHELIAL DYSFUNCTION AND DERANGED LEVEL OF ASYMMETRIC DIMETHYL ARGININE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. J Postgrad Med Inst [Internet]. 2015 Dec. 12 [cited 2024 Apr. 18];29(3). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/1700
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