THROMBO- EMBOLIC RISK IN HIGH ESTROGENIC PHASE OF NORMAL MENSTRUAL CYCLE IN HEALTHY WOMEN

Abstract

Objective: This study is conducted to compare the risk of thrombo-embolism
during different phases of menstrual cycles.
Methodology:105 healthy premenopausal unmarried females of 18 -21 years
with a history of previous three normal menstrual cycles and 32 age matched
male volunteers were recruited in the study. The phase of menstrual cycle of
female volunteers was established by taking menstrual history. Bleeding time
was determined by Duke's method.
Results: Bleeding time in 105 females was 73.03±1.89 Seconds and in 32
males was 69.33±4.94 Seconds which were not significantly different statis-tically (p=0.063). Among females, 69 volunteers were in follicular phase of
their hormonal cycle. Bleeding time in 29 females in early follicular phase was
70.86±3.38 Seconds and 40 females in late follicular phase was 68.25±4.03
Seconds. Statistically significant difference was not seen (p=0.095) when the
two phases were compared. Bleeding time is not found to be reduced in late
follicular phase as compared to early follicular phase, even high concentra -tion of estrogen is present in the body in this phase as per normal menstrual
physiology.
Conclusion: High Estrogen in normal menstrual cycle does not increase
thrombo-embolic risk in healthy women.