ROLE OF MALONDIALDEHYDE IN THE SERUM OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS
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Abstract
Objective: To measure malondialdehyde in order to determine oxidative
stress in rheumatoid arthritis and osteoarthritis subjects and comparing them
with healthy individuals.
Methodology Malondialdehyde estimation were done by using the UV-VIS
spectrophotometer in the department of biochemistry SP medical college,
Bikaner. Thiobarbituric acid assay method was used to estimate Malondial-dehyde .
Results: A statistically significant elevation of MDA level in serum of rheuma-toid arthritis (RA) and osteoarthritis (OA) subjects was seen (p<0.0001). The
serum MDA level was also significantly increased in the subjects than in the
controls. The serum MDA level was also significantly increased in the subjects
than in the controls.
Conclusion: Oxidative stress is due to increased free radical production which
is the main mechanism in the pathogenesis of of RA and OA.
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