EFFECT OF SMOKING ON INTERLEUKIN-6 AND CORRELATION BETWEEN IL-6 AND SERUM AMYLOID A-LOW DENSITY LIPOPROTEIN IN SMOKERS
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Published:
Dec 9, 2017
Keywords:
Cigarette smoking, Interleukin-6, Serum amyloid A-low density lipoprotein
Main Article Content
Abstract
Objective: To investigate the effect of smoking on interleukin-6 and to find the
correlation between serum amyloid A-low density lipoprotein (SAA-LDL) and
IL-6 in smokers.
Methodology: The study was a randomized control trial, carried out in Army
Medical College, Rawalpindi, from June 2014 to February 2015. Three hundred
healthy males participated in the study and were divided into two groups.
Group-I included non-smokers while group-II were smokers. Levels of SAALDL
and IL-6 were determined using ELISA kit. Data were analyzed using t-test.
Pearson correlation was used to find correlation between SAA-LDL and IL-6.
Results: IL-6 levels were high in the smokers than in non-smokers. The mean
of IL-6 levels of group I and group II was 40.03 ±8.06 and 50.43 ±19.67 respectively.
The difference was statistically significant (p <0.05). Moderate positive
association was found between SAA-LDL and IL-6 in smokers (r =0.651, n =150,
p <.05).
Conclusion: Positive association was found between smoking and IL-6. Statistically
significant moderate positive association between SAA-LDL and IL-6 in
smokers shows that changes in one are associated with changes in other and
vice versa.
correlation between serum amyloid A-low density lipoprotein (SAA-LDL) and
IL-6 in smokers.
Methodology: The study was a randomized control trial, carried out in Army
Medical College, Rawalpindi, from June 2014 to February 2015. Three hundred
healthy males participated in the study and were divided into two groups.
Group-I included non-smokers while group-II were smokers. Levels of SAALDL
and IL-6 were determined using ELISA kit. Data were analyzed using t-test.
Pearson correlation was used to find correlation between SAA-LDL and IL-6.
Results: IL-6 levels were high in the smokers than in non-smokers. The mean
of IL-6 levels of group I and group II was 40.03 ±8.06 and 50.43 ±19.67 respectively.
The difference was statistically significant (p <0.05). Moderate positive
association was found between SAA-LDL and IL-6 in smokers (r =0.651, n =150,
p <.05).
Conclusion: Positive association was found between smoking and IL-6. Statistically
significant moderate positive association between SAA-LDL and IL-6 in
smokers shows that changes in one are associated with changes in other and
vice versa.
Article Details
How to Cite
1.
Jamil A, Rashid A, Naveed AK, Asim M. EFFECT OF SMOKING ON INTERLEUKIN-6 AND CORRELATION BETWEEN IL-6 AND SERUM AMYLOID A-LOW DENSITY LIPOPROTEIN IN SMOKERS. J Postgrad Med Inst [Internet]. 2017 Dec. 9 [cited 2024 Dec. 18];31(4). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/2098
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