TRENDS IN ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS FROM ASYMPTOMATIC NASAL CARRIERS
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Published:
Dec 9, 2017
Keywords:
Staphylococcus aureus, Nasal carriers, Antibiobitcs
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Abstract
Objective: To evaluate the trends of antibiotic resistance pattern of Staphylococcus
aureus (S. aureus) isolated from nares of healthy volunteers.
Methodology: Participants belonging to, community associated (CA) and hospital
associated (HA) environment were included in the study. A total of 207
nasal swab samples were processed for the isolation of S. aureus using conventional
identification procedure. The antibiotic sensitivity testing for the isolates
was done using kirbey-baur disk diffusion test.
Results: S. aureus was found in 27% of the samples. Maximum resistance (60%)
was observed against erythromycin antibiotic. Statistically significant differences
were seen in the percentages of S. aureus resistance against clindamycin, ciprofloxacin
and methicillin between HA and CA. Odds ratio (OR) for clindamycin ,
ciprofloxacin and methicillin were calculated to be 5.91, 3.84 and 11.9 while the
p values were 0.015, 0.040 and 0.001 respectively.
Conclusion: An association of clindamycin and ciprofloxacin resistance with CA
S. aureus and a statistically significant association of methicillin resistance with
HA S. aureus were observed.
aureus (S. aureus) isolated from nares of healthy volunteers.
Methodology: Participants belonging to, community associated (CA) and hospital
associated (HA) environment were included in the study. A total of 207
nasal swab samples were processed for the isolation of S. aureus using conventional
identification procedure. The antibiotic sensitivity testing for the isolates
was done using kirbey-baur disk diffusion test.
Results: S. aureus was found in 27% of the samples. Maximum resistance (60%)
was observed against erythromycin antibiotic. Statistically significant differences
were seen in the percentages of S. aureus resistance against clindamycin, ciprofloxacin
and methicillin between HA and CA. Odds ratio (OR) for clindamycin ,
ciprofloxacin and methicillin were calculated to be 5.91, 3.84 and 11.9 while the
p values were 0.015, 0.040 and 0.001 respectively.
Conclusion: An association of clindamycin and ciprofloxacin resistance with CA
S. aureus and a statistically significant association of methicillin resistance with
HA S. aureus were observed.
Article Details
How to Cite
1.
Patoli AA, Patoli BB, Kumar D. TRENDS IN ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS FROM ASYMPTOMATIC NASAL CARRIERS. J Postgrad Med Inst [Internet]. 2017 Dec. 9 [cited 2024 Dec. 22];31(4). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/2132
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