EFFECTIVENESS AND SAFETY OF GABAPENTIN IN THE MANAGEMENT OF POST-OPERATIVE PAIN
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Abstract
Objective: To determine the effectiveness and safety of preoperative gabapen- tin administration on post-operative pain after laparoscopic cholecystectomy.
Methodology: Ninety patients undergoing laparoscopic cholecystectomy were divided into two groups. Group A received gabapentin in a dose of 300 mg two hours before surgery; and group B received placebo capsules in the same size and shape as gabapentin capsules. The pain scores, consumption of analgesics and adverse effects were compared between the two groups postoperatively at 2 hours, 6 hours, 12 hours and 24 hours after recovery.
Results: Group A had statistically less pain scores as compared to group B at 2, 6, 12 and 24 hours after recovery (p values were 0.0001, <0.0001, 0.0004, <0.0001 respectively). The requirement of analgesics was statistically lower in group A in comparison to group B at all the time intervals (p <0.0001). Both groups had no difference in the frequency of adverse effects except for vomit- ing which was significantly higher in group B (p =0.04).
Conclusion: Post-operative pain and the requirement for postoperative anal- gesics were significantly reduced in patients with administration of gabapentin before surgery and its use was found to be safe following laparoscopic chole- cystectomy.
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