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Mehreen Hameed
Fazle Raziq


Objective: To determine the prevalence of weak D phenotype among blood donor population.

Methodology: This cross-sectional review was conducted at Rehman Medical Institute, Peshawar from October 2018 to September 2019 and involved 4361 voluntary blood donors. Blood samples obtained for ABO and Rh D blood grouping were tested through conventional test tube technique. Agglutinating commercially available mon­oclonal anti-D sera were used for Rh D status detection. Du-testing was performed to identify weak-D phenotype. MS Excel and SPSS version-22 were used hands for statistical analysis.

Results: A total of 4361 blood samples were taken from recruited healthy blood donors (one sample per donor). Out of these 3786 (86.8%) were Rh D positive while 575 (13.2%) were Rh D negative. Among Rh D negative cases, three (0.5%) were weak-D positive constituting 0.5% among Rh D negatives and 0.06% from total donors screened.

Conclusion: This study concluded a very small prevalence of weak D in blood donor population. It is recommended that weak-D phenotype detection in Rh negative donors must be considered as an essential part of blood transfu­sion investigations to prevent risk of alloimmunization in recipients.

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How to Cite
Hameed M, Raziq F. PREVALENCE OF WEAK D PHENOTYPE IN BLOOD DONORS: A STUDY FROM TERTIARY CARE HOSPITAL. J Postgrad Med Inst [Internet]. 2021 Jun. 30 [cited 2024 Jun. 21];35(2):85-9. Available from:
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