COMPARATIVE STUDY BETWEEN GRANISETRON, ONDANSETRON AND PROPOFOL FOR THE PREVENTION OF EMESIS AFTER GYNAECOLOGICAL LAPROSCOPY

Abstract

Objective: The aim of this work was to evaluate the efficiency and safety of granisetron versus

ondansetron and Propofol for prevention of postoperative nausea and vomiting in patient undergoing day

case gynaecological laproscopy under general anaesthesia.

Material and Methods: This study was conducted in Alquwayiyah General Hospital and Riyadh Medical

Complex. K.S.A, over and period of six months, from January 2004 to June 2004 (both Months inclusive).

120 adult non pregnant female patients (18-40 yrs of age) of ASA I-II scheduled for diagnostic

gynaecological laproscopy were included in this study. Patients with severe systemic or endocrine disease

who had predisposing factors for delayed gastric emptying, such as diabetes, cholecystitis or

neuromuscular disorders were excluded.

Results: This study was conducted in 120 patients classified into six groups (20 patients each). The first

group received granisetron, the second group ondansetron, the third, fourth and fifth group received

propofol in different does. The last group received normal saline as placebo ( control group). Treatment

with either granisetron (group-I) and ondansetron (group-II) resulted in significant lower incidence of

nausea and vomiting over 12 hours observation postoperatively compared with other group. However

granisetron resulted in significant in lower incidence than ondansteron.

Conclusion: It is concluded that preoperative prophylactic administration of intravenous granisetron 40

ug/kg is effective and superior to ondansetron and propofol in preventing nausea and vomiting after

gynaecological laproscopic surgical procedures.