PREVALENCE AND RISK FACTORS ASSOCIATION WITH HEPATITIS B AND C INFECTED PREGNANT LADIES VISITING TERTIARY CARE HOSPITALS OF PESHAWAR: AN UNMATCHED PILOT CASE-CONTROL STUDY

Main Article Content

Jalwa Javed Farooqi
Farhat Rehana Malik
Fatima Noor
Kanza Javed

Abstract

Objective: To determine the prevalence, risk factors, and their association with Hepatitis B and C infection among pregnant females visiting Tertiary Care Hospitals of Peshawar.


Methods: A pilot case-control study was conducted in the Gynecology & Obstetrics units of Tertiary Care Hospitals of Peshawar after being approved by the institutional IRB Committee. A consecutive sampling technique was used to enroll 21 pregnant females in a ratio of 1: 1 among both groups. The included cases were HBsAg positive with ELIZA positive HCV while the negative ones were in the control group. A validated research tool from previous stud­ies was used. The collected data were analyzed through SPSS Version- 19. Descriptive and inferential statistics like frequency, percentages, 95% confidence interval, chi-square and odds ratio were applied with cut-off p-value limit set at 0.05.


Results: The mean age for cases and controls was 37±9 and 28±6 years. The seroprevalence of HBV was 28.9% and HCV as 61.9%. Abortion history OR=1.23 (95% Cl=0.34-4.35), hospitalization OR=2.90 (Cl=0.77-10.8), past surgical procedure OR=3.69 (Cl=0.81-16.6), dental extraction OR=1.25 (Cl=0.33-4.63), delivery in hospi­tal OR=4.26 (Cl=1.13-16.05), injection in hospitals OR=1.47 (Cl=0.43-5.04), household contact with jaundice OR=5.66 (Cl=1.41-22.7) were the significant risk factors. Normal vaginal delivery OR=1.96 (Cl=0.51-7.48) and history of sexually transmitted infections OR=2.23 (Cl=0.36-13.7) were independently associated with HBV, and HCV.


Conclusion: Hepatitis C prevalence rate was more with blood transfusions, unsafe injections, tooth extractions, home deliveries with past history of sexually transmitted infections, abortion, hepatitis infection, and hospital ad­missions as the significant risk factors among pregnant women.

Article Details

How to Cite
1.
Jalwa Javed Farooqi, Malik FRM, Noor F, Farooqi KJ. PREVALENCE AND RISK FACTORS ASSOCIATION WITH HEPATITIS B AND C INFECTED PREGNANT LADIES VISITING TERTIARY CARE HOSPITALS OF PESHAWAR: AN UNMATCHED PILOT CASE-CONTROL STUDY. J Postgrad Med Inst [Internet]. 2023 May 22 [cited 2024 May 30];37(2):91-6. Available from: https://jpmi.org.pk/index.php/jpmi/article/view/3176
Section
Original Article
Author Biography

Kanza Javed, Department of Medicine, Kuwait Teaching Hospital Peshawar & Department of Community Health Sciences, Peshawar Medical College, Riphah International University Islamabad- Pakistan

Gynecology & Obstetric Department. Mercy Teaching Hospital/ House Officer

References

World Health Organization. Hepatitis [Internet] [Cited 28th January, 2023; Updated 2023] Available from; https:// www.who.int/health-topics/hepati¬tis#tab=tab_1

Malekifar P, Babanejad M, Izadi N, Ala¬vian SM. The Frequency of HBsAg in Pregnant Women from Eastern Mediter¬ranean and Middle Eastern Countries: A Systematic Review and Meta-Analysis. Hepat Mon. 2018; 18 (9); DOI:10.5812/ hepatmon.58830

Afsheen Z, Ahmad B, Bashir S. Hospi¬tal-visiting pregnant women signal an increased spread of hepatitis C infec¬tion in Khyber Pakhtunkhwa region of Pakistan. Virology Journal; 2017; 14 (1):195. DOI; https://doi.org/10.1186/ s12985-017-0861-y

Jilani K, Zulfiqar B, Memon QB, Fahim MF. Frequency and the risk factors of hepatitis C virus in pregnant women; A hospital based descriptive study in Gadap Town Karachi. Pak J Med Sci. 2017; 33 (5): 1265- 8. DOI:10.12669/ pjms.335.12493

Javed N, Nadeem M, Ghazanfar H. Hepatitis B and C in Pakistan: A com¬munity survey. Cureus. 2019; 11 (10): DOI:10.7759/cureus.5992

Akhtar H, Badshah Y, Akhtar S, Hasan F, Faisal M, Zaidi NSS et al. Prevalence of hepatitis B and hepatitis C Virus in¬fections among male to female (MFT) transgenders in Rawalpindi (Pakistan). Adv. Life Sci. 2018; 5 (2): 46- 55.

Asghar MS, Rasheed U, Hassan M, Akram M, Yaseen R, Fayyaz B. Sero¬prevalence of Hepatitis B and Hepatitis C amongst the General Population of Rural Districts of Sind, Pakistan. Arq Gastroenterol. 2021; 58 (2): 150- 6: DOI: https://doi.org/10.1590/S0004- 2803.202100000-26

Barros MMO, Ronchini KROM, Soares RLS. Hepatitis B and C in pregnant women attended by a prenatal program in a university hospital in Rio De Janei¬ro, Brazil: Retrospective study of sero¬prevalence screening. Arq Gastroenter¬ol. 2018; 55 (3): 267- 3. DOI: 10.1590/ S0004-2803.201800000-68. PMID: 30540090.

Gedefaw G, Waltengus F, Akililu A, Ge¬laye K. Risk factors associated with hep¬atitis B virus infection among pregnant women attending antenatal clinic at Felegehiwot referral hospital, Northwest Ethiopia, 2018: an institution based cross sectional study. BMC Res Notes. 2019; 12 (509); 1- 7: DOI: https://doi. org/10.1186/s13104-019-4561-0

Israr M, Ali F, Nawaz A, Idrees M, Khattak A, Ur Rehman S, et al. Seroepidemiology and associated risk factors of hepatitis B and C virus infections among preg¬nant women attending maternity wards at two hospitals in Swabi, Khyber Pa¬khtunkhwa, Pakistan. PLoS ONE. 2021; 16 (8): e0255189: DOI: https://doi. org/10.1371/journal.pone.0255189

Bigna JJ, Kenne AM, Hamroun A, Ndan¬gang MS, Foka AJ, Tounouga DN, et al. Gender development and hepatitis B and C infections among pregnant wom¬en in Africa: a systematic review and meta-analysis. Infectious Diseases of Poverty; 2019; 8 (1): 16. DOI; https:// doi.org/10.1186/s40249-019-0526-8

Kebede KM, Abateneh DD, Belay AS. Hepatitis B virus infection among preg¬nant women in Ethiopia: a systematic review and Meta-analysis of prevalence studies. BMC Infect Dis. 2018; 18 (1): 322. DOI: 10.1186/s12879-018- 3234-2

Mekonnen BD. Prevalence of Hepati¬tis C Virus Infection among Pregnant Women in Ethiopia: A Systematic Re¬view and Meta-Analysis. Advances in Preventive Medicine. 2021; 2021: 6615008: 1- 8: DOI: https://doi. org/10.1155/2021/6615008.

Al Kanaani Z, Mahmud S, Kouyoumjian SP, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Pakistan: system¬atic review and meta-analyses. R Soc Open Sci. 2018; 5 (4): 180257. DOI: 10.1098/rsos.180257.

Zheng, S., Zhang, H., Chen, R. et al. Pregnancy complicated with hepatitis B virus infection and preterm birth: a retrospective cohort study. BMC Pregnancy Childbirth. 2021; 21 (513): DOI: https://doi.org/10.1186/s12884-021- 03978-0

Anteneh ZA, Wondaye E, Mengesha EW. Hepatitis B virus infection and its determinants among HIV positive preg¬nant women: Multicenter unmatched case-control study. PLoS ONE. 2021; 16 (4): DOI: https://doi.org/10.1371/ journal.pone.0251084

Sirilert S, Tongsong T. Hepatitis B Vi¬rus Infection in Pregnancy: Immuno¬logical Response, Natural Course and Pregnancy Outcomes. J Clin Med. 2021; 10 (13): 2926; DOI: 10.3390/ jcm10132926.

Mehmood, S., Raza, H., Abid, F. et al. National prevalence rate of hepatitis B and C in Pakistan and its risk factors. J Public Health. 2021; 28; 751– 64: DOI: https://doi.org/10.1007/s10389-019- 01081-5

He, S., Shuang, G., Yinglan, W. et al. Prevalence and factors associated with hepatitis C among pregnant women in China: a cross-sectional study. Sci Rep. 2023; 13 (759): DOI: https://doi. org/10.1038/s41598-023-27668-3.