Effects of Eugenia Jambolana and Zizyphus Sativa on Blood Glucose Levels of Normal and Alloxan Diabetic Rabbits
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Abstract
The alcoholic extracts of the seeds of Eugenia jambolana and leaves of Zizyphus sativa were administered in doses of 150 mg/kg and 250 mg/kg body weight to normal and alloxan-diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours after the administered of the extract of Eugenia jambolana exerted a significant (P < 0.05) hypoglycaemic effect in normal rabbits. The hypoglycaemic effect was not significant (P < 0.01) in alloxan-diabetic rabbits. The extract of Zizyphus sativa did not produced any significant (P < 0.01) hypoglycaemic effect in normal as well as in alloxan-treated diabetic rabbits. The doses used did not show any acute toxicity and behavioural changes. From this study it may be concluded that the extract of Eugenia jambolana acts by initiating the release of insulin from pancreatic beta cells of normal rabbits. Moreover, Zizyphus sativa, which is used as as anti-diabetic in folk medicine, did not show any hypoglycaemic effect in normal as well as in diabetic rabbits.
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