Efficacy of Tranexamic Acid In Reducing Blood Loss During Myomectomy; An Institutional Experience
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Abstract
Objective: To compare the efficacy of tranexamic acid versus placebo in reducing intraoperative blood loss during myomectomy, assessed by postoperative haemoglobin level.
Material & Methods: This randomized controlled trial (RCT) was conducted in Gynecology & Obstetrics department of department of Nishtar Medical University, Multan from 01-01-2024 to 31-12-2024. Total 90 patients were divided equally into two groups on the basis, they received iinjectable tranexamic acid or placebo. The main outcome was measured by checking postoperative haemoglobin levels to ascertain the intraoperative blood loss irrespective of blood transfusions during surgery. Data was analyzed using SPSS version 25. Post stratification t-test for quantitative data and Chi square test for qualitative variables was applied. P-value ≤ 0.05 was considered significant.
Results: Two study groups were similar in demographic characteristics including the age, parity, BMI and change in perioperative Hemoglobin (Hb) levels. Change in Hb in two groups was 0.2 ± 0.2 vs 4.9 ± 1.2 (p= 0.01). There was significant difference in need of blood transfusion, 11% vs 44% (p=0.04).
Conclusion: Tranexamic acid significantly reduces myomectomy-associated blood loss, and need for further blood transfusions.
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