Effect of Diclofenac Sodium In Renal Colic

Abstract

Pakistan being located in the geographic belt of high incidence of stone disease, and having hot climatic conditions during summer months, faces the problem of insufficient number of hospitals with limited number of in-patient facilities. On the other hand calculus renal disease is a common urological problem with its common presenting symptom as real colic, often necessitating hospital admission. Moreover, the high incidence of stone diseases in a stage of transition from the lower urinary tract to the upper tract with its close relation to industrialization and socio-economic development.

The most common cause of renal colic is a calculus impacted in the ureter or less frequently passage of blood clot, sloughed papilla and crystalluria. The incidence of crytalluria and colic dramatically rise during the summer months.

For many years it was assumed that ureteric spasm is responsible for the pathogenesis of pain. Thus the conventional treatment with spasmolytics and antimuscarinic drugs used to be instituted in the treatment of renal colic. The response of human ureteral tissue to acetylcholine is variable and no conclusions can be drawn concerning the presence or absence of muscrainic receptors, hence one can not expect antimuscarinic drugs like atropine, hyoscine butylbromide and prppanthaline bromide to be effective in renal colic, and pain relief afforded by these drugs is poor.