PROTHROMBIN TIME AS AN INDICATOR OF SEVERITY OF LIVER DISEASES
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Keywords:
Prothrombin time, liver disease, indicator
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Abstract
Objective: To confirm that Prothrombin time is by and large the most sensitive indicator of hepatocellular function.
Material and Methods: Two hundred and twenty patients were recruited in the study from Military Hospital Rawalpindi and combined Military Hospital Peshawar over one year period 1993. All the patient went through a detailed history, hematological and screening tests. The student 't' test was used to assess the significance of results obtained.
Results: 97% of the patients were males while 69% of the total patients were in the age group of 21-30 years. 93% had viral hepatitis and out of these only 19.50% were Hbs Ag positive. The common symptoms in order of frequency were yellow sclera, loss of appetite, dark urine. Jaundice (97.2%) and palpable liver (81.36) were the most common physical signs. Patients who had PT difference less than 3 seconds from the control had mild hepatitis, while patients who had PT difference more than 3 seconds from the control, had severe hepatitis.
Conclusion: PT is a good prognostic indicator of severity of liver diseases and correlates well with the elevation of bilirubin and ALT.
Material and Methods: Two hundred and twenty patients were recruited in the study from Military Hospital Rawalpindi and combined Military Hospital Peshawar over one year period 1993. All the patient went through a detailed history, hematological and screening tests. The student 't' test was used to assess the significance of results obtained.
Results: 97% of the patients were males while 69% of the total patients were in the age group of 21-30 years. 93% had viral hepatitis and out of these only 19.50% were Hbs Ag positive. The common symptoms in order of frequency were yellow sclera, loss of appetite, dark urine. Jaundice (97.2%) and palpable liver (81.36) were the most common physical signs. Patients who had PT difference less than 3 seconds from the control had mild hepatitis, while patients who had PT difference more than 3 seconds from the control, had severe hepatitis.
Conclusion: PT is a good prognostic indicator of severity of liver diseases and correlates well with the elevation of bilirubin and ALT.
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Niazi M. PROTHROMBIN TIME AS AN INDICATOR OF SEVERITY OF LIVER DISEASES. J Postgrad Med Inst [Internet]. 2011 Jul. 27 [cited 2024 Nov. 18];23(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/73
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