COMPARISON OF TREATMENT WITH TACROLIMUS 0.03% AND SUPEROXIDE DISMUTASE AND CATALASE IN VITILIGO
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Keywords:
Vitiligo, Depigmentation, Tacrolimus, Superoxide dismutase and catalase
Main Article Content
Abstract
Objective: To compare the efficacy and safety of topical tacrolimus 0.03% with superoxide dismutase and
catalase in vitiligo.
Material and methods: This hospital based quasi-experimental study was carried out in out patients
department of Dermatology Unit-II, Mayo Hospital Lahore in year 2006-2007. Patients were selected by
non-probability purposive sampling method after obtaining an informed consent. Both sexes (above 5
years) were included with head and neck vitiligo. They were randomly divided into 2 groups; group 1:
superoxide dismutase and catalase; group 2: tacrolimus by using random number table.
Results: There were 34(56.7%) females and 26(43.3%) males. Age of the patients ranged from 5 to 60
years with the mean age of 20.52+14.34 years. Overall 31(62%) patients showed repigmentation of varied
grades. Repigmentation was shown by 14(46.6%) patients in superoxide dismutase & catalase group and
17(56.6%) patients in tacrolimus group.
Conclusion: Topical superoxide dismutase & catalase and tacrolimus are effective treatment modalities in
patients with vitiligo. There is no significant difference regarding efficacy and safety between both forms of
treatment.
catalase in vitiligo.
Material and methods: This hospital based quasi-experimental study was carried out in out patients
department of Dermatology Unit-II, Mayo Hospital Lahore in year 2006-2007. Patients were selected by
non-probability purposive sampling method after obtaining an informed consent. Both sexes (above 5
years) were included with head and neck vitiligo. They were randomly divided into 2 groups; group 1:
superoxide dismutase and catalase; group 2: tacrolimus by using random number table.
Results: There were 34(56.7%) females and 26(43.3%) males. Age of the patients ranged from 5 to 60
years with the mean age of 20.52+14.34 years. Overall 31(62%) patients showed repigmentation of varied
grades. Repigmentation was shown by 14(46.6%) patients in superoxide dismutase & catalase group and
17(56.6%) patients in tacrolimus group.
Conclusion: Topical superoxide dismutase & catalase and tacrolimus are effective treatment modalities in
patients with vitiligo. There is no significant difference regarding efficacy and safety between both forms of
treatment.
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How to Cite
1.
Paracha MM, Khurshid K, Pal SS, Ali Z. COMPARISON OF TREATMENT WITH TACROLIMUS 0.03% AND SUPEROXIDE DISMUTASE AND CATALASE IN VITILIGO. J Postgrad Med Inst [Internet]. 2011 Oct. 13 [cited 2024 Dec. 22];24(2). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/1224
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