SALIVARY, PLASMA AND CORD BLOOD OXIDATIVE STRESS BIOMARKERS IN MOTHER AND NEONATE: A COMBINED ANALGESIA CONCERN

Abstract

Objective: To measure oxidative stress biomarkers in saliva and venous blood
of mothers and cord blood of newborns delivered wih and without combined
analgesia.
Methodology: In this analytical cross-sectional study, carried out in 2015. 68
parturient mothers and newborns were recruited in random to two groups in
Fatemieh Teaching Hospital, Hamadan City, Iran. Thirty four of them were delivered
via normal vaginal delivery (NVD) and 34 delivered through combined
analgesia (CA). This study was designed to measure total antioxidant capacity
(TAC), Total thiol molecules (TTM) and catalase activity (CAT), in blood and saliva
of mothers at the second stage of labor and cord blood of newborns delivered
through these different delivery modes.
Results: No significant difference could be observed in the mean of first and
third labor stages in CA and NVD groups, but the difference was significant
during the second stage in CA and NVD groups, respectively. No statistically
significant difference was noticed between the means of oxidative stress parameters
(TTM, TAC and CAT) in plasma, saliva and umbilical cord samples in
two groups (P> 0.05). A significant positive correlation existed between (plasma
and umbilical cord TAC) and (plasma and saliva CAT). There was no significant
relationship between newborn birth weight and oxidative stress parameters in
two groups.
Conclusion: Markers of oxidative stress does not seem to have a major role in
the delivery with combined analgesia.