COMPARISON OF 3.0% HYPERTONIC SALINE VERSUS 0.9% NORMAL SALINE NEBULIZATION FOR ACUTE BRONCHIOLITIS IN CHILDREN
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Abstract
Objective: To compare the use of 3.0% hypertonic saline versus 0.9% normal saline for nebulization in children who presented with acute bronchiolitis.
Methodology: We included 76 children having age less than 2 years who pre- sented with acute bronchiolitis in Emergency Department of Nishtar Hospital, Multan, from September 2016 to April 2107. In group I patients, 0.9% normal saline was used for nebulization; and in group II patients 3.0% hypertonic sa- line was used for nebulization. Nebulization was repeated after every 6 hours. Reduction in modified respiratory assessment (MRA) score after 48 hours and hospital stay were primary outcomes of study.
Results: In our study, most of children were in age group of <6 months. The MRA score after 48 hours of nebulization was 4.89 +1.22 in normal saline group versus 3.34 +1.05 in patients of hypertonic saline group (p value <0.001). Re- duction in MRA score was more in hypertonic saline group as compared to normal saline group. Mean hospital stay was 4.47 +1.03 days in normal saline group and 3.47 +0.89 in hypertonic saline group (P value <0.001).
Conclusion: Hypertonic saline resulted in significant reductions in modified re- spiratory assessment score (MRAS) and hospital stay as compared to normal saline in children with acute bronchiolitis.
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