ACUTE MOTOR AXONAL NEUROPATHY IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A CASE REPORT

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Uzma Akhlaque
Saeed Bin Ayaz

Abstract

Development of acute motor axonal neuropathy (AMAN) in children with acute lymphoblastic leukemia (ALL) is a rare phenomenon and needs to be differentiated from neuropathy induced by chemotherapeutic agents as both require different treatment protocols. The later may warrant adjustments in the chemotherapy regimen. Electrodiagnostic (EDX) studies play the key role in this differentiation. We report here an 11-year-old girl with ALL who presented with signs and symptoms of a rapidly progressive neuropathy diagnosed as AMAN through EDX studies, and achieved a better recovery following timely immunomodulatory therapy, electrical muscle stimulation of the key muscle groups, and therapeutic exercises. The differentiation between AMAN and chemotherapeutics' induced neuropathy through EDX studies is important in children with ALL to initiate timely immunomodulatory therapy for AMAN and avoid unnecessary withdrawal of chemotherapeutic agents.

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How to Cite
1.
Akhlaque U, Ayaz SB. ACUTE MOTOR AXONAL NEUROPATHY IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A CASE REPORT. J Postgrad Med Inst [Internet]. 2020 Jul. 14 [cited 2024 Mar. 28];34(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/2522
Section
Case Report
Author Biographies

Uzma Akhlaque, Armed Forces Institute of Rehabilitation Medicine Rawalpindi 46000, Pakistan

Consultant Physical Medicine and Rehabilitation

Saeed Bin Ayaz, Combined Military Hospital, Jhelum 49600, Punjab, Pakistan

Head of the Department, Rehabilitation Medicine