COMPARISON OF DEXIBUPROFEN VERSUS IBUPROFEN AS AN ANTIPYRETIC IN FEBRILE CHILDREN- A RANDOMIZED CLINICAL TRIAL

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Adnan
Khawaja Kamran Wahid
Amir Mohammad

Abstract

Objective: To compare the efficacy of dexibuprofen and ibuprofen for management of fever in febrile children.


Methodology: This randomized clinical trial was conducted at the Pediatric Department, Lady Reading Hospital, Peshawar-Pakistan from October 2019 to April 2020. A total 150 patients were randomly allocated into two arms (Group I; dexibuprofen and Group II; Ibuprofen) and were enrolled through non-probability consecutive sampling technique. Participants between the ages of 6 months and 12 years, with febrile illness were enrolled in this study. Data analysis was done using Stata version 14, independent samples t-test was applied to compare mean change in temperature between the groups at different stages.


Results: The mean age of the participants in the study was 2.84±1.655 years. The number of males were 107(71.33%) and females were 43(28.67%). There was no statistical difference in axillary temperature of par­ticipants in both groups before the intake of analgesics (p=0.527). The mean temperature after 4 hour of using dexibuprofen (100.14± 1.27 0F) was lower than ibuprofen (101.29±1.23 0F) with statistically significant differ­ence (p<0.001).


Conclusion: Dexibuprofen and ibuprofen are both effective in control of febrile illness but mean reduction in tem­perature for dexibuprofen was statistically more significant than ibuprofen.

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1.
Adnan, Khawaja Kamran Wahid, Mohammad A. COMPARISON OF DEXIBUPROFEN VERSUS IBUPROFEN AS AN ANTIPYRETIC IN FEBRILE CHILDREN- A RANDOMIZED CLINICAL TRIAL. J Postgrad Med Inst [Internet]. 2021 Dec. 31 [cited 2022 Nov. 30];35(4):210-3. Available from: https://jpmi.org.pk/index.php/jpmi/article/view/2917
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