Initial Experience with I131 MIBG Imaging In Patients With Neuroblastoma
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Abstract
Metaiodobenzyl quanidine was synthesized from metaiodobenzyl amine hydrochloride and cyanamide at different temperatures. The yield was found to be 60-70%. The product was characterized by UV, IR, and NMR spectroscopic techniques. The characterized product was labelled with iodine -131 and labeling efficiency was determined by radio-TLC technique. Labeling yield up to 95% was achieved. Five patient with biopsy proven neuroblastoma were imaged. In two patients intrabdominal primary tumor was successfully localized and a thoracic metastatic site was detected in one of them. MIBG scanning was normal in remaining three patients.
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Khan HA, Shah AS, Khan SM, Ahmad I, Syed GS. Initial Experience with I131 MIBG Imaging In Patients With Neuroblastoma. J Postgrad Med Inst [Internet]. 2011 Aug. 25 [cited 2024 Dec. 21];7(2). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/435
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