To sty the etiology of unexplained cervical lymphadenoapthy of more than one month duration, not easily diagnosed on clinical ground or after simple investigations. This study was conducted at LRH, peshawar from January 2003 to June 2004. A total of 100 patients with prolonged unexplained cervical lymphadenopathies were included in this study. All the patients were evaluated through detailed history and clinical examination. Beside these, laboratory, radiological, endoscopic examination, FNAC and histopathological studies were performed. Tuberculous lymphadenitis (58%) represented the commonest infectious aetiology in present study and carcinoma is less common as compared to the western figures. It is advised that any treatment for cervical lymphadenopathy should be preceded by histological proof.