CORRELATION BETWEEN GLYCOSYLATED HEMOGLOBIN AND PLATELET ACTIVITY AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS
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Abstract
Objective: To determine the correlation between glycosylated hemoglobinlevel and platelet activity among patients with type 2 diabestes mellitus(T2DM).
Methodology: This study was conducted in the Department of Medicine,Khyber Teaching Hospital, Peshawar from January to June 2012. Through aComparative Cross Sectional Study Design, a total of 80 patients with T2DMwere selected from Medical Wards and OPDs and were grouped into thosewith glycated hemoglobin (HbA1c) levels < 7% (Group A, n=33) and thosewith HbA1c ≥ 7% (Group B, n=47 patients). Both the groups were comparedwith regards to MPV and HbA1c.
Results: The mean age of patients was 47.41 ± 6.74 years. In group A there were 45.5% (15) males and 54.5% (18) females. In group B there were 48.9%(23) males and 51.1% (24) female patients. MPV was significantly higher in group B as compared to group A (9.21±0.76 fl vs. 8.29±0.46 fl; P < 0.001).Among the group B patients, a positive statistical Pearson's correlation was seen between MPV and HbA1c levels (r = 0.589; p < 0.001). However, no statistical correlation was seen between MPV and the duration of DM and BMI.
Conclusions: There is a significant association between poor glycemic controland increased platelet activity in patients with uncontrolled T2DM.
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