COMPARATIVE STUDY OF CLINICAL EFFICACY OF DILTIAZEM AND PROPRANOLOL IN PATIENTS WITH HYPERTHYROIDISM

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Mushtaq Ahmad Marwat
Muhammad Jan
Shabbir Ali Bhatti
Muhammad Rauf

Abstract

Objective: To compare the efficacy of diltiazem and propranolol in controlling the adrenergic manifestations of hyperthyroidism.

Material and Methods: This prospective, interventional study included 44 newly diagnosed, untreated patients with hyperthyroidism attending the out patient department of Institute of Radiotherapy and Nuclear Medicine, Peshawar. Patients were randomized to two matched groups. Group I (n = 23, mean age 37.91 + 10.48 years) took diltiazem 30 mg three times a day for 6 weeks. Group II (n = 21, mean age 37.57 + 14.27 years) took propranolol 20 mg three times a day for a period of 6 weeks. Clinical assessment was done before starting therapy and then after 6 weeks (+ 3 days) using standardized and

modified hyperthyroid symptom score (HSS).

Results: HSS decreased from 16.35 + 2.31 to 11.26 + 2.56 in group I after 6 weeks of therapy with diltiazem (P < 0.001). HSS declined from 15.62 + 2.25 to 11.38 + 2.13 in group II after 6 weeks of therapy with propranolol (P < 0.001).

Conclusion: Diltiazem, like propranolol, effectively controls the clinical manifestations of

hyperthyroidism.

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How to Cite
1.
Marwat MA, Jan M, Bhatti SA, Rauf M. COMPARATIVE STUDY OF CLINICAL EFFICACY OF DILTIAZEM AND PROPRANOLOL IN PATIENTS WITH HYPERTHYROIDISM. J Postgrad Med Inst [Internet]. 2011 Aug. 16 [cited 2022 Oct. 7];23(3). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/255
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