Summary Peptic ulcer is a common ailment for which gastric acid secretion is the main cause. This study was conducted to observe the effects of histamine H-receptors anatagonist ranitidine and calciumchannel blocker verapamil on the volume, free acidity and total acidity of carbachol induced gastric secretion. Eighteen albino rats of Sprague Dawley strain weighing 150-200 grams were used. After fasting for 48 hours,pylorusof each animal was ligated,verapamil 10 mg/Kg, ranitidine 0.5 mg/Kg and carbachol reduced both the volume and acidity of gastric secretion which were statistically highly significant when compared with carbachol (P < 0.001). Similarly verapamil also reduced volume, free acidity and total acidity which were highly significant when compared with carbachol. When the differences of means brough about by ranitidine were compared with those of verapamil, all these differences were statistically non significant indicating that acidity induced by carbachol and it may be used effectively in the treatment of peptic ulcer.