Evaluation of Effect of Extract from Seeds of Myristica Fragrans on Volume and Acidity of Stimulated Gastric Secretion Liver and Kidney Function

Abstract

This study was conducted to observe the effect of extracts from the seeds of medicinal plant "Myristica Fragrans" (which has documented calcium channel blocker) on volume and acidity of carbachol induced gastric secretion, liver and kidney function in fasting rabbits. Thirty rabbits of local breed were included in the study and they were divided into three equal groups. Group A was injected with carbachol. Group B was injected with extract and carbachol and Group C was injected only extract and liver and kidney function was determined. The drugs and extract were injected intraperitoneally. It is concluded that the extract is an excellent inhibitor of gastric acid secretion and can be safely used for peptic ulcer and otheer diseases which need calcium channel blockers for their treatment. This will also enalb a lay man to use the crude drug obtained from esily available local plant.