Diagnostic Accuracy Of Ultrasound In Detecting Malignant Thyroid Nodules Keeping Histopathology As Gold Standard
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Abstract
Objective: To determine the diagnostic accuracy of ultrasound in the detecting malignant thyroid nodule keeping histopathology as a gold standard.
Methodology: In the current study a total of 164 patients were included. A detail history, routine hospital investigations and physical examination for the included patients were performed. Patients were subjected to ultrasound in Radiology department where the ultrasound was done by the senior resident under the supervision of expert radiologist having more than 7 years of ex-perience. The nodules were reported according to ACR TI-RADS. Then the patients were referred to ENT department where the incisional biopsy were performed and the specimen was sent to hospital laboratory for the diagnosis of malignant thyroid nodule. All the histopathological examinations were done by expert histo-pathologist having more than 7 years of experience.
Results: In this study total 164 patients were included and mean age was 34 years with SD ± 7.318. Male patients were 62(38%) while 102(62%) patients were female. Ultrasound had sensitivity 96.58%, specificity 83.33%, positive predictive value 76.65%, negative predictive value 97.72% and the diagnostic accuracy was 88.12%.
Conclusion: Our study concludes that ultrasound had sensitivity 96.58%, specificity 83.33%, positive predictive value 76.65%, neg-ative predictive value 97.72% and the diagnostic accuracy was 88.12% in the detecting malignant thyroid nodule keeping histo-pathology as a gold standard.
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References
Bchir A, Bdioui A, Zammel H , Missaoui N , Hmissa S , Mokni M. The importance of using fine-needle aspiration cytology in the diagnosis of thyroid nodules. Ann Med surg. 2021; 26(4):102-18
Ramundo V, Sponziello M, Falcone R. Low-risk papillary thyroid microcarcinoma: optimal management toward a more conservative approach. J Surg Oncol.2020;121(6):958-63.
Filetti S, Durante C, Hartl D.Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol.2019;30(12):1856-83.
Pizzato M, Li M, Vignat J, Laversanne M, Singh D, Vecchia CL et al. The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020.Lancet Diabetes Endocrinol.2022;10(4): 264-72.
Chen DW, Lang BH, McLeod DA, Newbold K, Haymart MR.Thyroid cancer. The Lancet. 2023; 401: 1531-44.
Chen Q, Lin M and Wu S. Validating and Comparing C-TIRADS, K-TIRADS and ACR-TIRADS in Stratifying the Malignancy Risk of Thyroid Nodules.Front.Endocrinol.2022;13:3389-95
Alam T, Khattak YJ, Beg M, Raouf A, Azeemuddin M, Khan AA. Diagnostic accuracy of ultrasonography in differentiating benign and malignant thyroid nodules using fine needle aspiration cytology as the reference standard. Asian Pac J Cancer Prev. 2014;15(22):10039–43.
Jiang S, Xie Q, Li N, Chen H, and Chen X. Modified models for predicting malignancy using ultrasound characters have high accuracy in thyroid nodules with small size. Frontiers in Molecular Biosciences.2021; vol. 8:1-8.
Jasim S, Baranski TJ, Teefey SA, Middleton WD. Investigating the effect of thyroid nodule location on the risk of thyroid cancer. Thyroid.2020;30(3):401-07.
Ramundo V, Lamartina L, Falcone R. Is thyroid nodule location associated with malignancy risk? Ultrasonography. 2019;38(3):231-35.
Singaporewalla RM, Hwee J, Lang TU, and Desai V. Clinico-pathological correlation of thyroid nodule ultrasound and cytology using the TIRADS and bethesda classifications. World Journal of Surgery.2017;41:1807–11.
Li L, Chen X, Li P, Liu Y, Ma X, and Ye YQ. The value of ultrasound-guided fine-needle aspiration cytology combined with puncture feeling in the diagnosis of thyroid nodules. Acta Cytologica.2021;65:368–76.
Maddaloni E, Briganti SI, Crescenzi A ,Anguissola GB, Perrella E, Taffon C et al. Usefulness of color Doppler ultrasonography in the risk stratification of thyroid nodules. Eur Thyroid J.2021; 10: 339–44.
Grani G, Sponziello M, Pecce V, Ramundo V and Durante C. Contemporary thyroid nodule evaluation and management. Journal of Clinical Endocrinology and Metabolism. 2020; 105:2869–83.
Perri F, Giordano A, Pisconti S, Franco I, Maria GC, Francesco L, et al.Thyroid cancer management: from a suspicious nodule to targeted therapy. Anti-Cancer Drugs.2018;29:483–90.
Bauer AJ. Thyroid nodules in children and adolescents. Current Opinion in Endocrinology Diabetes and Obesity.2019; 26:266–74.
Gild ML, Chan M, Gajera J, Lurie B, Gandomkar Z and Clifton-Bligh RJ. Risk stratification of indeterminate thyroid nodules using ultrasound and machine learning algorithms. Clinical Endocrinology.2022;96:646–52.
Li L and Qiu X. Safety and efficacy of ultrasound-guided radiofrequency ablation for benign nonfunctional thyroid nodules in children: a retrospective study of 62 patients with over four years of follow-up.Thyroid.2022; 32:525–35.
Watanabe K, Igarashi T, Ashida H, Ogiwara S, Ohta T, Uchiyama M. Diagnostic value of ultrasonography and TI-201/Tc-99m dual scintigraphy in differentiating between benign and malignant thyroid nodules. Endocr. 2019;63(2):301-9.
Barr CR, Bojunga J, Cantisani V, Chammas MC, Dighe M, Vinayak S. WFUMB guidelines and recommendations on the clinical use of ultrasound elastography: Part 4 Thyroid. Ultras Med Biol 2017;43:4-26.
Hoang JK, Middleton WD and Tessler FN. Update on ACR TI-RADS: Successes, Challenges, and Future Directions, From the AJR Special Series on Radiology Reporting and Data Systems. Am J Roentgenol. 2021; 216(3): 570-78.
Watanabe K, Igarashi T, Ashida H, Ogiwara S, Ohta T, Uchiyama M. Diagnostic value of ultrasonography and TI-201/Tc-99m dual scintigraphy in differentiating between benign and malignant thyroid nodules. Endocr. 2019;63(2):301-9.
Nawaz S,Khan MB,Parveen B,Asif M, Rashid M and Azeem M et al. Diagnostic Accuracy Of Thyroid Ultrasound In Detection Of Malignancy In Thyroid Nodules. Pak J Physiol.2018;14(3):11-13.
Al-Ghanimi IA, Al-Sharydah AM, Al-MulhimS, Faisal S, Al-Abdul wahab A and Al-Aftan A, et al. Diagnostic Accuracy of Ultrasonography in Classifying Thyroid Nodules Compared with Fine-Needle Aspiration. Saudi J Med Med Sci. 2020; 8(1): 25–31.