Peflacin (Pefloxacin) in the treatment of Typhoid Fever

Abstract

Twenty Five patients (mean age of 23.9 years) with clinical diagnosis of typhoid fever supported with positive widal test and / or blood / bone marrow culture were included in the trial. Most of the patient had already used Chloramphenicol and Amoxycillin without any effect. Peflacin (Pefloxacin) was administered orally to all patients at a daily dose of 800mg (400 mg B.D) for seven days. Clinical cure was achieved in all patients and 90% of them were apyrexial on the 4^th day of treatment. They remained apyrexial for 4 weeks after completion of treatment. Patient compliance was god and well tolerated the drug.