Evaluation of the liver protective potential Calendula Officinalis Flower extract on Paracetamol induce damage

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Jamshed Ali
Abdul Qayyum
Hameed Khan

Abstract

The hepatprotective activity of methanolic extract of calendula officinalis flower was investigated against paracetamol induced hepatic damage. Paracetamol at a dose of 640 mg/kg body weight produced liver damage in rats, as manifested by the rise in serum levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate trasaminase (GPT) and alkaline phosphatase (ALP) to 246+6.46, 247+4.61 and 393.0+7.54 IU/L (n=10) respectively, compared to respective control values of 54.5+1.45, 34+1.55 and 207.2+4.33 IU/L. Pre treatment of animals with plant extract (500 mg/kg body weight) significantly lowered  (p < 0.05) the respective serum GOT, GPT and ALP to 76.7+1.74, 68.3+3.9 and 208.8+4.48 IU/L. These results indicate that the crude extract of calendula officinalis flowers exibits hepatoprotective action.

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1.
Ali J, Qayyum A, Khan H. Evaluation of the liver protective potential Calendula Officinalis Flower extract on Paracetamol induce damage. J Postgrad Med Inst [Internet]. 2011 Sep. 12 [cited 2022 Sep. 24];13(2). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/669
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