Inherited Disorders of Prothrombin Not uncommon in Northern Pakistan

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Alia Zaidi
Liaqat Ali

Abstract

Coagulation screening tests and factor assays were done on fifty suspected cases of hereditary coagulation defects. Six patients (12%) of hereditary prothrombin deficiency were detected out of 15(30%) cases of rare autosomal recessive clotting defects while 35(70%) cases were due to factor VIII and factor IX defects. Teh age of presentation of all the patients was below on year. Clinically all of 6 patients presented with severe bleeding manifestations. They all showed marked prolongation of prothrombiin time (P.T) and activated partial thromboplastin time (APTT) and factor level was less than 10% in five out of six patients. 

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1.
Zaidi A, Ali L. Inherited Disorders of Prothrombin Not uncommon in Northern Pakistan. J Postgrad Med Inst [Internet]. 2011 Sep. 12 [cited 2022 Sep. 24];13(2). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/672
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Original Article

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