EFFECT OF CHRONIC HASHISH CONSUMPTION ON LIVER FUNCTION AND COAGULATION PROFILE IN HASHISH USERS
Article Sidebar
Main Article Content
Abstract
Objective: To study the effect of hashish consumption on liver function and coagulation parameters.
Methodology: Chronic hashish consumers (n=62) and healthy controls (n=43) were studied. Serum bilirubin, Liver enzymes alanine transaminase and alkaline phosphatase were studied to evaluate hepatic malfunctioning using manual colorimetric method. The coagulation parameters prothrombin time and activated partial thromboplastin time were studied to evaluate the risks of bleeding disorders using manual-tilt method.
Results: An increase in the blood levels of total bilirubin (P= 0.014), alanine transaminase (P= 0.024) and alkaline phosphatase (P= 0.025) was observed in chronic hashish consumers as compared to the non-hashish using group. A significant prolongation in prothrombin time (P= 0.026) and activated partial thromboplastin time (P= 0.029) was found in chronic hashish consumers as compared to the control group.
Conclusion: An increase in the levels of liver enzymes and coagulation parameters were observed in hashish users as compared to the control group which indicates that hashish consumption affect the liver functions.
Article Details
Work published in JPMI is licensed under a
Creative Commons Attribution-NonCommercial 2.0 Generic License.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.