THE DIAGNOSTIC VALIDITY OF PRE-OPERATIVE SERUM CA125 LEVEL IN WOMEN WITH OVARIAN MASSES

Main Article Content

Farnaz .
Samdana Wahab
Lubna Hassan

Abstract

Objective:

 

To determine the validity of serum CA125 levels in differentiating benign and ovarian cancer in

Methodology:

 

st

April, 2009 and 31st

March 2010.

In this cross sectional study, blood samples were obtained from 85 women with ovarian

masses who fulfilled the inclusion criteria and sent for the assay of serum CA125 levels. They were

scheduled for elective surgery at Hayatabad Medical Complex Hospital between 1st April 2009 and 31st March 2010.

Results:

Of the 85 women enrolled, ovarian cancer was found in 27 cases (31.8%) and benign ovarian

mass in 58 cases (68.2%). The sensitivity, specificity, and accuracy of serum CA125 at the cutoff level of

35 U/mL for prediction of ovarian cancer were 74.14%, 92.5%, 80% respectively; with 95.56% positive

predictive value and 62.5% negative predictive value.

Conclusion: 

As stand-alone modality, serum CA125 of more than 35 U/mL in predicting ovarian cancer

revealed modest diagnostic accuracy.

patients with ovarian masses, using histopathology as a gold standard.

Article Details

How to Cite
1.
. F, Wahab S, Hassan L. THE DIAGNOSTIC VALIDITY OF PRE-OPERATIVE SERUM CA125 LEVEL IN WOMEN WITH OVARIAN MASSES. J Postgrad Med Inst [Internet]. 2011 Dec. 29 [cited 2021 Nov. 27];26(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/1196
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Original Article

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