SINGLE DOSE VERSUS MULTI DOSE CEPHRADINE AS ANTIBIOTIC PROPHYLAXIS IN ELECTIVE ABDOMINAL HYSTERECTOMY: A RANDOMIZED CONTROL TRIAL
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Keywords:
Antibiotic prophylaxis, single dose, multiple dose, cephradine, abdominal hysterectomy, wound infection, randomized controlled trial.
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Abstract
Objective: To compare the efficacy of single dose versus 7 days cephradine prophylaxis for the prevention of post operative infection in patients undergoing elective abdominal hysterectomy.
Material and Methods: This study was conducted in the department of Obstetrics and Gynaecology, Lady Reading Hospital from January 2006 to March 2007. Twenty patients each were randomly allocated by card method to either group 1 or group II. Patients in group-1 were given one gram of cephradine intravenously 30 minutes before surgery while patients in group-II were given one gram of intravenous cephradine 30 minutes before surgery 2nd dose of one gram was repeated after 12 hours followed by 500 mg of oral dose for next 6 days. Wound was examined on 2nd, 4th and 7th day then after 2 weeks and
after 6 weeks. The efficacy was measured in terms of febrile morbidity, surgical and nonsurgical site infection and duration of hospital stay. The statistical analysis was carried out by chi square test.
Results: Febrile morbidity was equal in both groups (20%), surgical site infection was 10% in group I and 5% in group II, and duration of hospital stay was equal in both groups. Non surgical site infection occurred in 5% of patients in group-I. There was no statistically significant difference in out come in two groups.
Conclusion: Single dose prophylactic antibiotic is as effective as multiple dose antibiotics in elective abdominal hysterectomy.
Material and Methods: This study was conducted in the department of Obstetrics and Gynaecology, Lady Reading Hospital from January 2006 to March 2007. Twenty patients each were randomly allocated by card method to either group 1 or group II. Patients in group-1 were given one gram of cephradine intravenously 30 minutes before surgery while patients in group-II were given one gram of intravenous cephradine 30 minutes before surgery 2nd dose of one gram was repeated after 12 hours followed by 500 mg of oral dose for next 6 days. Wound was examined on 2nd, 4th and 7th day then after 2 weeks and
after 6 weeks. The efficacy was measured in terms of febrile morbidity, surgical and nonsurgical site infection and duration of hospital stay. The statistical analysis was carried out by chi square test.
Results: Febrile morbidity was equal in both groups (20%), surgical site infection was 10% in group I and 5% in group II, and duration of hospital stay was equal in both groups. Non surgical site infection occurred in 5% of patients in group-I. There was no statistically significant difference in out come in two groups.
Conclusion: Single dose prophylactic antibiotic is as effective as multiple dose antibiotics in elective abdominal hysterectomy.
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Jabeen S, Rahim R. SINGLE DOSE VERSUS MULTI DOSE CEPHRADINE AS ANTIBIOTIC PROPHYLAXIS IN ELECTIVE ABDOMINAL HYSTERECTOMY: A RANDOMIZED CONTROL TRIAL. J Postgrad Med Inst [Internet]. 2011 Aug. 9 [cited 2024 Nov. 22];21(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/149
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