TO COMPARE THE EFFECTIVENESS OF NIFEDIPINE AND GLYCERYL TRINITRATE PATCH IN PREVENTION OF PRETERM LABOUR
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Published:
Feb 6, 2016
Keywords:
Preterm labour, Nifedipine, Glyceryl trinitrate
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Abstract
Objective: To assess the effectiveness of Nifedipine and Glyceryl trinitrate
patch in prolonging the pregnancy for more than 48 hours.
Methodology: This was a randomized control study. Fifty patients with
preterm labour meeting the inclusion criteria were inducted in study and ran-domly allocated to the treatment group A (Nifedipine) and group B (Glyceryl
trinitrate patch, GTN). After taking consent from the patients, all the details
were documented on a proforma and tocolysis was started with either of
these tocolytics according to a preset protocol.
Results: Nifedipine was found to be more effective than GTN, as prolongation
of pregnancy beyond 48 hours was more frequent (74 %) with nifedipine than
GTN (40%) with P value <0.05 . Similarly prolongation beyond 7 days was also
more frequent (32%) with nifedipine as compared with GTN (24%). Most com-mon adverse effect found with nifedipine was headache followed by palpita-tions and hypotension. GTN patch had a better side effect profile with most
of the patients being asymptomatic. Fetal distress was noticed more in GTN
group as compared with nifedipine.
Conclusion: Nifedipine, as a tocolytic, is found to be more effective in preg-nancy prolongation when compared with Glyceryl trinitrate but has frequent
maternal adverse drug effects. Glyceryl trinitrate patch is well tolerated by the
patients with preterm labour with relatively fewer side effects.
patch in prolonging the pregnancy for more than 48 hours.
Methodology: This was a randomized control study. Fifty patients with
preterm labour meeting the inclusion criteria were inducted in study and ran-domly allocated to the treatment group A (Nifedipine) and group B (Glyceryl
trinitrate patch, GTN). After taking consent from the patients, all the details
were documented on a proforma and tocolysis was started with either of
these tocolytics according to a preset protocol.
Results: Nifedipine was found to be more effective than GTN, as prolongation
of pregnancy beyond 48 hours was more frequent (74 %) with nifedipine than
GTN (40%) with P value <0.05 . Similarly prolongation beyond 7 days was also
more frequent (32%) with nifedipine as compared with GTN (24%). Most com-mon adverse effect found with nifedipine was headache followed by palpita-tions and hypotension. GTN patch had a better side effect profile with most
of the patients being asymptomatic. Fetal distress was noticed more in GTN
group as compared with nifedipine.
Conclusion: Nifedipine, as a tocolytic, is found to be more effective in preg-nancy prolongation when compared with Glyceryl trinitrate but has frequent
maternal adverse drug effects. Glyceryl trinitrate patch is well tolerated by the
patients with preterm labour with relatively fewer side effects.
Article Details
How to Cite
1.
Yasmin S, Sabir S, Zahoor F. TO COMPARE THE EFFECTIVENESS OF NIFEDIPINE AND GLYCERYL TRINITRATE PATCH IN PREVENTION OF PRETERM LABOUR. J Postgrad Med Inst [Internet]. 2016 Feb. 6 [cited 2024 Dec. 22];30(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/1886
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