CLINICO-PATHOLOGICAL PRESENTATION AND THERAPEUTIC OPTIONS FOR HAIRY CELL LEUKEMIA
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Keywords:
Hairy cell leukemia (HCL), clinical presentation, treatment, interferon, cladribine, Pakistan
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Abstract
Objective: To look at clinical and hematological presentation as well as treatment outcome of patients with
diagnosis of Hairy Cell Leukemia (HCL) in our population.
Methodology: All patients diagnosed with HCL by morphological and immunohistochemical methods
presenting to Medical Oncology Ward at Hayatabad Medical Complex, Peshawar since August 2008 were
included in the study.
Results: Out of 7 patients diagnosed with HCL, 6 were male and 1 was female (M:F ratio 6:1). Median
age at diagnosis was 44 years. Fever, pallor, palpitations and fatigue were the commonest presenting
complaints. Spleenomegaly was noted in all patients (100%). Pancytopenia was noted in all patients at
presentation. Five patients were treated with Interferon while 2 were treated with Cladribine. At 18 months
of follow-up, one out five patients treated with IFN had relapse while both the patients treated with
Cladribine were in complete remission.
Conclusion: Our study showed that HCL patients present at a younger age in our region but further
studies with larger sample size are required to confirm this. All patients showed a complete response to
Interferon and Cladribine with all patients alive at 18 months of follow-up.
diagnosis of Hairy Cell Leukemia (HCL) in our population.
Methodology: All patients diagnosed with HCL by morphological and immunohistochemical methods
presenting to Medical Oncology Ward at Hayatabad Medical Complex, Peshawar since August 2008 were
included in the study.
Results: Out of 7 patients diagnosed with HCL, 6 were male and 1 was female (M:F ratio 6:1). Median
age at diagnosis was 44 years. Fever, pallor, palpitations and fatigue were the commonest presenting
complaints. Spleenomegaly was noted in all patients (100%). Pancytopenia was noted in all patients at
presentation. Five patients were treated with Interferon while 2 were treated with Cladribine. At 18 months
of follow-up, one out five patients treated with IFN had relapse while both the patients treated with
Cladribine were in complete remission.
Conclusion: Our study showed that HCL patients present at a younger age in our region but further
studies with larger sample size are required to confirm this. All patients showed a complete response to
Interferon and Cladribine with all patients alive at 18 months of follow-up.
Article Details
How to Cite
1.
Jameel A, Chiragh S, Iqbal S, Farooq M. CLINICO-PATHOLOGICAL PRESENTATION AND THERAPEUTIC OPTIONS FOR HAIRY CELL LEUKEMIA. J Postgrad Med Inst [Internet]. 2012 Jun. 29 [cited 2024 Apr. 23];26(3). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/1309
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