Summary In a prospective study all diagnosed cases of Gestational trophoblastic tumours (GTT) are placed in a risk group, low risk, medium risk, high risk using the WHO prognostic scoring system, Single agent or multiple agent chemotherapy is then commenced and the officacy and safety evaluated. The second objective is to see if it is possible to manage these patients in a general gynaecological ward and to find constraints if any. Seven patients have so far received treatment n our unit acordingto the new prognostic scoring system. Two wee in the low risk group and so received methotrexae and folinic acid rescue chemotherapy, one medium risk and four high risk.All responded well to therapy as judged by the regression in the beta DCG levels. Three patients have achieved a biochemical remission (cured) by first line chemotherapy. The treatment of the rest is ongoing. None had major side effects from the chemotherapy. None have so far developed resistance to the allotted chemotherapuetic regime.